WebUrinary CTGF excretion is reduced in patients with diabetic nephropathy treated with Losartan, an angiotensin converting enzyme inhibitor. In sum, these studies clearly show that there is a correlation between CTGF expression and fibrogenesis, but do not prove a cause-and-effect relationship between CTGF and fibrosis. WebAug 6, 2024 · Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli and lead to kidney fibrosis. Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling …
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WebAug 6, 2024 · CTGF expression in fibrosis is also reported to occur in the kidney area. Exposure of mesangial cell to recombinant human CTGF significantly increased production of fibronectin and collagen type I. Induction of CTGF in rat mesangial cells due to high glucose levels is mediated by TGF-β [ 12 ]. WebApr 11, 2024 · Nevertheless, clinical observations have shown that CTGF expression in the sera and fibrotic liver tissues of CHB patients is upregulated. A strong correlation … do you get interest on current accounts
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WebAug 25, 2009 · Connective tissue growth factor (CTGF) is a secreted protein that is strongly induced in human and experimental heart failure. CTGF is said to be profibrotic; however, the precise function of CTGF is unclear. We generated transgenic mice and rats with cardiomyocyte-specific CTGF overexpression (CTGF-TG). To investigate CTGF as a … WebJun 13, 2005 · Elevated production of CTGF might be responsible for maintenance of the fibrotic phenotype in scleroderma. Assays of CTGF or of its fragments are potential non-invasive measures of the fibrotic response in scleroderma. Aim: To determine the utility of whole, N-terminal, and C-terminal CTGF as surrogate markers for fibrosis in scleroderma. WebMay 19, 2024 · Among those, CTGF is a key mediator of ECM production, leading to proliferation of lung fibroblasts and progression of lung fibrosis. CTGF does not behave like a traditional growth factor or ... cleaning suede with alcohol