WebFeb 11, 2010 · This partial restoration of paclitaxel sensitivity is related to the multifactorial nature of drug resistance and the fact that the paclitaxel-resistant NSCLC cells have other microtubule... WebIt has been approximately ten years since the Food and Drug Administration (FDA) approved paclitaxel for the treatment of platinum resistant epithelial ovarian carcinoma. …
Paclitaxel Tablets (paclitaxel): Uses, Dosage, Side Effects
WebFeb 27, 2006 · Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp 26 Glu) and less stable microtubules Malathi Hari; Frank Loganzo; Tami Annable; Xingzhi Tan; Sylvia Musto; Daniel B. Morilla; James H. Nettles; James P. Snyder; Lee M. Greenberger Author & Article Information Mol Cancer Ther (2006) 5 (2): 270–278. WebClass III beta-tubulin (TUBB3) reduces microtubule stability and confers resistance to microtubule-stabilizing taxanes, including paclitaxel and docetaxel. Pancreatic ductal adenocarcinomas show limited responsiveness to taxanes, but little is known of the underlying mechanisms. chalk airways crash video
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding
WebThe cellular uptake, intracellular nanoparticle trajectory, and subsequent cellular events were evaluated after treatment with various PLGA nanocomplexes in human lung cancer A549 cells and A549-derived paclitaxel-resistant A549/T12 cell lines with -tubulin mutation.Results: A549 and A549/T12 cells contain constitutively activated Stat3, and ... WebApr 14, 2024 · The role of miR-18a and increased autophagy is corroborated by another study that shows how paclitaxel-resistant MDAMB231 cells have higher basal levels of both miR-18a ... autophagy in breast cancer cells, it also leads to hyperacetylation of tubulin, thus hindering the fusion of lysosomes and autophagosomes, which results in … WebThe cellular uptake, intracellular nanoparticle trajectory, and subsequent cellular events were evaluated after treatment with various PLGA nanocomplexes in human lung cancer … chalk airplane